Manion Anderson was born and raised in Pascagoula, Mississippi. Manion graduated from Pascagoula High School before going to the University of Southern Mississippi in Hattiesburg. While enrolled at Southern Miss, Manion was an active member of Kappa Sigma Fraternity, the Inter-Fraternity Council, and the Society of Physics Students – holding numerous officer positions within each. Manion graduated from Southern Miss in four years with a Bachelor of Science degree in Physics.

Manion received his law degree from Louisiana State University in Baton Rouge, Louisiana. He spent one year as a visiting student at the University of Oklahoma in Norman, Oklahoma. As a law student, Manion held numerous clerkship positions with several firms around the nation including Legal Services Corporation in Baton Rouge, LA, Neil P. McGuffee, PC in Oklahoma City, OK, and Tynes Law Firm in Pascagoula, MS.
Manion and his wife Sarah have two daughters and one son.

Manion is still actively involved in the local Kappa Sigma Fraternity chapter and is also a member of the Area Developmental Partnership, Pine Belt Young Professionals, and the Young Lawyers Division of the Mississippi Bar.

Manion and his family also invest significant time as members of Heritage United Methodist Church, where Manion serves on the Church Council and Finance Committee. Sarah teaches Godly Play and serves on the Heritage Preschool Board. Manion also serves on the Southern Miss Athletic Foundation Board.